Article
Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIalpha.
The Biochemical journal - 15 Dec 1998
Aoyama M, Grabowski D R, Dubyak G R, Constantinou A I, Rybicki L A, Bukowski R M, Ganapathi M K, Hickson I D, Ganapathi R
Abstract excerpt
Topoisomerase II (topo II), an essential enzyme for cell viability, is also the target for clinically important anti-neoplastic agents that stimulate topo II-mediated DNA scission. The role of alterations in topo IIalpha phosphorylation and its effect on drug-induced DNA damage and cytotoxicity were investigated. Following loading of HL-60 cells with the calcium buffer 1,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.