Article
The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.
Japanese journal of cancer research : Gann - 1 Oct 1998
Yoshinaga K, Sasano H, Furukawa T, Yamakawa H, Yuki M, Sato S, Yajima A, Horii A
Abstract excerpt
To pursue the pathogenesis of endometrial carcinogenesis, we investigated microsatellite instability, mutations in the PTEN, TGF beta RII, IGFIIR, and BAX genes, and LOHs on 10q in 18 putative endometrial premalignant lesions (11 endometrial atypical hyperplasias (ATHs), 2 complex hyperplasias, a...
Topics
- Endometrial Neoplasms
- Endometrium
- Exons
- Female
- Genes, Tumor Suppressor
- Humans
- Hyperplasia
- Loss of Heterozygosity
- Microsatellite Repeats
- Mutation
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Precancerous Conditions
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins