Article
TGF-beta1 gene mutations in insulin-dependent diabetes mellitus and diabetic nephropathy.
Journal of the American Society of Nephrology : JASN - 1 Dec 1998
Pociot F, Hansen P M, Karlsen A E, Langdahl B L, Johannesen J, Nerup J
Abstract excerpt
PCR assays were established for easy and fast analysis of two transforming growth factor-beta1 (TGF-beta1) gene mutations, a C to T transition at position 76 in exon 5 resulting in a change from threonine to isoleucine in position 263 (Thr263Ile) of the propeptide and a deletion of a C in the int...
Topics
- Amino Acid Substitution
- DNA Mutational Analysis
- DNA, Complementary
- Denmark
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Gene Expression Regulation
- Genotype
- Introns
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sequence Deletion
- Tetradecanoylphorbol Acetate
- Transforming Growth Factor beta