Quantitative analysis of yeast gene function using competition experiments in continuous culture.

doi:10.1002/(SICI)1097-0061(199811)14:15<1417::AID-YEA334>3.0.CO;2-N

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Quantitative analysis of yeast gene function using competition experiments in continuous culture.

Yeast (Chichester, England) - 1 Nov 1998

Baganz F, Hayes A, Farquhar R, Butler P R, Gardner D C, Oliver S G

Abstract excerpt

One possible route to the evaluation of gene function is a quantitative approach based on the concepts of metabolic control analysis (MCA). An important first step in such an analysis is to determine the effect of deleting individual genes on the growth rate (or fitness) of S. cerevisiae. Since the specific growth-rate effects of most genes are likely to be small, we employed competition experiments in chemostat...

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Quantitative analysis of yeast gene function using competition experiments in continuous culture.

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