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Article

Extragenic suppressors of yeast glucose derepression mutants leading to constitutive synthesis of several glucose-repressible enzymes.

Journal of bacteriology - 1 Mar 1991

Schüller H J, Entian K D

Abstract excerpt

Saccharomyces cerevisiae regulatory genes CAT1 and CAT3 constitute a positive control circuit necessary for derepression of gluconeogenic and disaccharide-utilizing enzymes. Mutations within these genes are epistatic to hxk2 and hex2, which cause defects in glucose repression. cat1 and cat3 mutants are unable to grow in the presence of nonfermentable carbon sources or maltose. Stable gene disruptions were...

Topics

Alleles
Deoxyglucose
Enzyme Repression
Epistasis, Genetic
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Suppressor
Genetic Complementation Test
Gluconeogenesis
Glucose
Hexokinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 2002006
DOI: 10.1128/jb.173.6.2045-2052.1991
PMCID: PMC207739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2002006-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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