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Article

In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.

Journal of virology - 1 Dec 1991

Trousdale M D, Steiner I, Spivack J G, Deshmane S L, Brown S M, MacLean A R, Subak-Sharpe J H, Fraser N W

Abstract excerpt

Many recent studies of latent herpes simplex virus type 1 (HSV-1) infections within the nervous system have focused on the diploid genes encoding the latency-associated transcripts (LATs). The impaired explant reactivation of LAT variants from mouse trigeminal ganglia has implicated the LATs in the efficiency or speed of the reactivation process (D. A. Leib, C. L. Bogard, M. Kosz-Vnenchak, K. A. Hicks, D. M....

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Share to Chromosome Deletion
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 1658388
DOI: 10.1128/JVI.65.12.6989-6993.1991
PMCID: PMC250813

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.PMID 1658388Read ↗

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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivationSemantic proximity Read ↗

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Interrelationship of Primary Virus Replication, Level of Latency, and Time to Reactivation in the Trigeminal Ganglia of Latently Infected MiceSemantic proximity Read ↗

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