Article
In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.
Journal of virology - 1 Dec 1991
Trousdale M D, Steiner I, Spivack J G, Deshmane S L, Brown S M, MacLean A R, Subak-Sharpe J H, Fraser N W
Abstract excerpt
Many recent studies of latent herpes simplex virus type 1 (HSV-1) infections within the nervous system have focused on the diploid genes encoding the latency-associated transcripts (LATs). The impaired explant reactivation of LAT variants from mouse trigeminal ganglia has implicated the LATs in t...
Topics
- Animals
- Chromosome Deletion
- DNA, Viral
- Eye
- Genetic Variation
- Genome, Viral
- Kinetics
- Organ Culture Techniques
- Rabbits
- Simplexvirus
- Transcription, Genetic
- Trigeminal Ganglion
- Virus Activation