Article
An HSV-1 mutant lacking the LAT TATA element reactivates normally in explant cocultivation.
Virology - 1 Oct 1993
Deshmane S L, Nicosia M, Valyi-Nagy T, Feldman L T, Dillner A, Fraser N W
Abstract excerpt
In order to examine if mutations within the LAT promoter region of HSV-1 are sufficient to change the reactivation phenotype, a mutant (KOS/29) containing a deletion of the LAT TATA element was used to establish latent infections in mouse ganglia by corneal inoculation. During the acute phase of infection, KOS/29 replicated as efficiently as its wild-type parent. As previously noted, latent KOS/29 infections were...
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