Article
Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury.
American journal of respiratory and critical care medicine - 1 Dec 1998
Kristof A S, Goldberg P, Laubach V, Hussain S N
Abstract excerpt
The role of nitric oxide (NO) in lung injury remains unclear. Both beneficial and detrimental roles have been proposed. In this study, we used mutant mice lacking the inducible nitric oxide synthase (iNOS) to assess the role of this isoform in sepsis-associated lung injury. Wild-type and iNOS kno...
Topics
- Animals
- Blood Vessels
- Bronchi
- Bronchoalveolar Lavage Fluid
- Coloring Agents
- Disease Models, Animal
- Endotoxins
- Epithelium
- Escherichia coli
- Female
- Follow-Up Studies
- Isoenzymes
- L-Lactate Dehydrogenase
- Lipopolysaccharides
- Lung
- Macrophages, Alveolar
- Male
- Mice