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Article

Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury.

American journal of respiratory and critical care medicine - 1 Dec 1998

Kristof A S, Goldberg P, Laubach V, Hussain S N

Abstract excerpt

The role of nitric oxide (NO) in lung injury remains unclear. Both beneficial and detrimental roles have been proposed. In this study, we used mutant mice lacking the inducible nitric oxide synthase (iNOS) to assess the role of this isoform in sepsis-associated lung injury. Wild-type and iNOS knockout mice were injected with either saline or Escherichia coli endotoxin (LPS) 25 mg/kg and killed 6, 12, and 24 h...

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Identifiers

PMID: 9847282
DOI: 10.1164/ajrccm.158.6.9802100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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