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Article

The αvβ3 Integrin Regulates α5β1-mediated Cell Migration toward Fibronectin

1 Nov 1997

Abstract excerpt

This study examines the interactions of alphavbeta3 and alpha5beta1 in the regulation of cell migration. Human embryonic kidney (HEK) 293 cells that express alpha5beta1 endogenously were transfected with alphavbeta3 and beta3 mutants, and their attachment and migration to fibronectin (Fn) and vitronectin (Vn) were measured. An alphavbeta3 blocking antibody and the alphavbeta3 ligand cyclic G-Pen-GRGDSPC-A...

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Identifiers

PMID: 9361020
DOI: 10.1074/jbc.272.46.29380

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