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Article

Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting

8 Dec 1998

Abstract excerpt

Myostatin, a member of the transforming growth factor-beta superfamily, is a genetic determinant of skeletal muscle growth. Mice and cattle with inactivating mutations of myostatin have marked muscle hypertrophy. However, it is not known whether myostatin regulates skeletal muscle growth in adult men and whether increased myostatin expression contributes to wasting in chronic illness. We examined the hypothesis...

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Share to HIV-related health complications and treatments
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PMID: 9843994
DOI: 10.1073/pnas.95.25.14938

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