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Article

Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth.

American journal of human genetics - 1 Dec 2006

Saunders Matthew A, Good Jeffrey M, Lawrence Elizabeth C, Ferrell Robert E, Li Wen-Hsiung, Nachman Michael W

Abstract excerpt

Myostatin (GDF8) is a negative regulator of muscle growth in mammals, and loss-of-function mutations are associated with increased skeletal-muscle mass in mice, cattle, and humans. Here, we show that positive natural selection has acted on human nucleotide variation at GDF8, since the observed ratio of nonsynonymous:synonymous changes among humans is significantly greater than expected under the neutral model and...

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Source

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Identifiers

PMID: 17186467
DOI: 10.1086/509707
PMCID: PMC1698719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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