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Article

Neuroattenuated bunyavirus variant: derivation, characterization, and revertant clones.

Journal of virology - 1 May 1990

Endres M J, Valsamakis A, Gonzalez-Scarano F, Nathanson N

Abstract excerpt

A neuroattenuated variant bunyavirus, designated RFC/25B.5 (B.5), was selected by serial passage of a reassortant clone (RFC virus) of a California serogroup virus in BHK-21 cells, followed by plaque purification of that passaged stock. Based on its virulence index (ratio of PFU/50% lethal dose), clone B5 was over 40,000-fold less virulent than its unpassaged RFC parent after intracerebral (i.c.) inoculation into...

Topics

Animals
Antigens, Viral
Brain
Bunyaviridae
Cell Line
Fluorescent Antibody Technique
Genetic Variation
Kinetics
Mice
Virulence
Virus Replication

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Identifiers

PMID: 2182907
DOI: 10.1128/JVI.64.5.1927-1933.1990
PMCID: PMC249346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2182907-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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