Article
A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding.
Molecular pharmacology - 1 May 1994
Piersen C E, True C D, Wells J N
Abstract excerpt
The amino acids that comprise the ligand binding sites of adenosine receptors have not been identified. Adenosine and its agonist analogues differ from ligands for the well studied biogenic amine receptors and rhodopsin in that the adenosine receptor agonists are larger, contain a ribose moiety,...
Topics
- Adenosine
- Affinity Labels
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Blotting, Western
- Dogs
- Glycosylation
- Histidine
- Iodobenzenes
- Ligands
- Molecular Sequence Data
- Mutation
- Rabbits
- Radioligand Assay
- Receptors, Purinergic P1
- Structure-Activity Relationship