Article
Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8.
Age (Dordrecht, Netherlands) - 1 Aug 2013
Bayram Banu, Nikolai Sibylle, Huebbe Patricia, Ozcelik Beraat, Grimm Stefanie, Grune Tilman, Frank Jan, Rimbach Gerald
Abstract excerpt
In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n = 10 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit β-5. Furthermore, heme...
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