Article
Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase.
The Journal of biological chemistry - 4 Dec 1998
Lubkowski J, Yang F, Alexandratos J, Merkel G, Katz R A, Gravuer K, Skalka A M, Wlodawer A
Abstract excerpt
Crystallographic studies of the catalytic core domain of avian sarcoma virus integrase (ASV IN) have provided the most detailed picture so far of the active site of this enzyme, which belongs to an important class of targets for designing drugs against AIDS. Recently, crystals of an inactive D64N...
Topics
- Amino Acid Sequence
- Asparagine
- Aspartic Acid
- Avian Sarcoma Viruses
- Binding Sites
- Catalytic Domain
- Cations, Divalent
- Hydrogen Bonding
- Hydrogen-Ion Concentration
- Integrases
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Conformation