Article
Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase.
The Journal of biological chemistry - 4 Dec 1998
Lubkowski J, Yang F, Alexandratos J, Merkel G, Katz R A, Gravuer K, Skalka A M, Wlodawer A
Abstract excerpt
Crystallographic studies of the catalytic core domain of avian sarcoma virus integrase (ASV IN) have provided the most detailed picture so far of the active site of this enzyme, which belongs to an important class of targets for designing drugs against AIDS. Recently, crystals of an inactive D64N mutant were obtained under conditions identical to those used for the native enzyme. Data were collected at different...
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