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Article

Hyperoxia synergistically increases TNF-alpha-induced interleukin-8 gene expression in A549 cells.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2000

Allen G L, Menendez I Y, Ryan M A, Mazor R L, Wispé J R, Fiedler M A, Wong H R

Abstract excerpt

Interleukin (IL)-8 is an important mediator of acute lung injury. Hyperoxia induces IL-8 production in some cell types, but its effect on IL-8 gene expression in respiratory epithelium is not well described. In addition, IL-8 gene expression resulting from the combined effects of hyperoxia and proinflammatory cytokines has not been well characterized. We treated cultured respiratory epithelial-like cells (A549...

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PMID: 10666108
DOI: 10.1152/ajplung.2000.278.2.L253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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