H2O2 and tumor necrosis factor-alpha activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter.

doi:10.1074/jbc.270.32.18966

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Article

H2O2 and tumor necrosis factor-alpha activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter.

The Journal of biological chemistry - 11 Aug 1995

Roebuck K A, Rahman A, Lakshminarayanan V, Janakidevi K, Malik A B

Abstract excerpt

We investigated the mechanisms by which H2O2 increases intercellular adhesion molecule 1 (ICAM-1; CD54) expression in endothelial cells. The H2O2-induced increase in ICAM-1 mRNA was inhibited by actinomycin D, by the antioxidant N-acetylcysteine, and by 3-amino-benzamide (which blocks oxidant-induced AP-1 activity), but not by pyrrolidine dithiocarbamate (which blocks oxidant-induced NF-kappa B activity). Nuclear...

Topics

Animals
Base Sequence
DNA
Humans
Hydrogen Peroxide
Intercellular Adhesion Molecule-1
Mice
Molecular Sequence Data
Mutation
Oligonucleotides, Antisense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

RNA, Messenger

Rats

Transcription Factor AP-1

Transcription, Genetic

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 7642556
DOI: 10.1074/jbc.270.32.18966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7642556-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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