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Article

Molecular cloning of Saccharomyces cerevisiae MLF4/SSH4 gene which confers the immunosuppressant leflunomide resistance.

Biochemical and biophysical research communications - 19 May 1998

Fujimura H

Abstract excerpt

Immunosuppressant leflunomide inhibits the growth of cytokine-stimulated lymphoid cells in vitro and also inhibits the growth of eukaryotic microorganism Saccharomyces cerevisiae. To elucidate the molecular mechanism of the action of the drug, a yeast gene which suppresses the anti-proliferative effect when in increased copy number was cloned and designated MLF4 for multicopy suppressor of leflunomide...

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Source

Identifiers

PMID: 9610367
DOI: 10.1006/bbrc.1998.8630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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