Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased DNA polymerase fidelity of the Lamivudine resistant variants of human hepatitis B virus DNA polymerase.

Journal of biochemistry and molecular biology - 31 Mar 2004

Hong Young Bin, Choi Yongwook, Jung Guhung

Abstract excerpt

Although efficient antiviral lamivudine is used for HBV-infected patients, a prolonged treatment with nucleoside analogs often results in lamivudine-resistant variants. In this study, we evaluated the fidelity of the lamivudine-resistant variants. The FLAG-tagged wild-type (FPolE) and Met550 variants (FPolE/M550A, M550V, and M550I) of HBV DNA polymerases were expressed in insect cells, then purified. Like many...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Baculoviridae
Share to Base Pair Mismatch
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Exonucleases

Share to HIV Reverse Transcriptase

Share to Lamivudine

Share to Spodoptera

Share to Templates, Genetic

Source

Identifiers

PMID: 15469692
DOI: 10.5483/bmbrep.2004.37.2.167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased DNA polymerase fidelity of the Lamivudine resistant variants of human hepatitis B virus DNA polymerase.PMID 15469692Read ↗

Fidelity of hepatitis B virus polymeraseSemantic proximity Read ↗

Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo.Semantic proximity Read ↗

Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase.Semantic proximity Read ↗

Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro.Semantic proximity Read ↗

[Construction of whole-genome lamivudine-resistant hepatitis B virus mutant and its replication and expression in HepG2 cells].Semantic proximity Read ↗

YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection.Semantic proximity Read ↗

Reverse transcriptase activity of hepatitis B virus (HBV) DNA polymerase within core capsid: interaction with deoxynucleoside triphosphates and anti-HBV L-deoxynucleoside analog triphosphates.Semantic proximity Read ↗

The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance.Semantic proximity Read ↗

Construction and expression of eukaryotic plasmids containing lamivudine-resistant or wild-type strains of Hepatitis B Virus genotype C.Semantic proximity Read ↗

Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus.Semantic proximity Read ↗

Kinetic analysis of wild-type and YMDD mutant hepatitis B virus polymerases and effects of deoxyribonucleotide concentrations on polymerase activity.Semantic proximity Read ↗

In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.