Article
Effects of c-raf-1 and c-myc expression on radiation response in an in vitro model of human small-cell-lung carcinoma.
Biochemical and biophysical research communications - 18 Nov 1998
Pfeifer A, Mark G, Leung S, Dougherty M, Spillare E, Kasid U
Abstract excerpt
In this study we examined the radiation survival response of simian virus 40 large tumor antigen-immortalized human bronchial epithelial cells (BEAS-2B) stably transfected with c-raf-1 and/or c-myc. C-raf-1 transfectants (2B-raf), and c-raf-1 and c-myc double transfectants (2B-raf/myc) were relat...
Topics
- Carcinoma, Small Cell
- Cell Cycle
- Gene Expression
- Genes, myc
- Humans
- Lung Neoplasms
- Phenotype
- Proto-Oncogene Proteins c-raf
- Proto-Oncogenes
- RNA, Messenger
- RNA, Neoplasm
- Radiation Tolerance
- Superoxide Dismutase
- Transfection
- Tumor Cells, Cultured