Article
Smooth muscle cell phenotype-dependent transcriptional regulation of the alpha1 integrin gene.
The Journal of biological chemistry - 17 Oct 1997
Obata H, Hayashi K, Nishida W, Momiyama T, Uchida A, Ochi T, Sobue K
Abstract excerpt
The expressional regulation of chicken alpha1 integrin in smooth muscle cells was studied. The alpha1 integrin mRNA was expressed developmentally and was distributed dominantly in vascular and visceral smooth muscles in chick embryos. In a primary culture of smooth muscle cells, alpha1 integrin expression was dramatically down-regulated during serum-induced dedifferentiation. Promoter analyses revealed that the...
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