Article
Characterization of a mammalian smooth muscle cell line that has retained transcriptional and posttranscriptional potencies.
In vitro cellular & developmental biology. Animal - 1 Jan 2004
Pasquet S, Thiebaud P, Faucheux C, Olive M, Fourcade S, Lalevee N, Lamaziere J-M Daniel, Theze N
Abstract excerpt
Unlike skeletal and cardiac muscle cells that differentiate irreversibly, smooth muscle cells (SMCs) retain a high degree of plasticity. During the so-called phenotypic modulation, SMCs can undergo transition between a contractile phenotype and a highly proliferative synthetic phenotype, as apparent from the extinction of numerous smooth muscle (SM) markers when they are passaged in culture. It would be very...
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