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Article

Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data.

Pharmaceutical research - 1 Apr 2009

Kusama Makiko, Maeda Kazuya, Chiba Koji, Aoyama Akinori, Sugiyama Yuichi

Abstract excerpt

PURPOSE: The *2 and *3 alleles of CYP2C9, with decreased enzymatic activity, are highly polymorphic and contribute to inter-individual differences in pharmacotherapy of CYP2C9 substrates. Here, we sought for a simplified theoretical method to predict the pharmacokinetic changes with minimal in vivo data. METHODS: The changes in clearances of CYP2C9 substrates in subjects with these alleles were quantitatively...

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Administration, Oral
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C9
Gene Expression Regulation, Enzymologic
Metabolic Clearance Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacokinetics

Reproducibility of Results

Substrate Specificity

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PMID: 19082874
DOI: 10.1007/s11095-008-9781-2

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