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Article

Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk.

British journal of cancer - 1 Nov 1998

Agúndez J A, Martínez C, Olivera M, Gallardo L, Ladero J M, Rosado C, Prados J, Rodriguez-Molina J, Resel L, Benítez J

Abstract excerpt

The role of two common polymorphisms of enzymes involved in the metabolism of drugs and carcinogens was studied in relation to prostate cancer. The gene encoding one of these enzymes (NAT2) is located in an area where frequent allelic loss occurs in prostate cancer. Mutations at the genes CYP2D6 and NAT2 were analysed by allele-specific polymerase chain reaction and restriction mapping in DNA from 94 subjects...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9823980
DOI: 10.1038/bjc.1998.685
PMCID: PMC2063181

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk.PMID 9823980Read ↗

Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer.Semantic proximity Read ↗

Variation in N-acetyltransferase 2 (NAT2), smoking and risk of prostate cancer in the Slovak population.Semantic proximity Read ↗

Pharmacogenetics, Regulation and Structural Properties of the Drugmetabolizing Enzymes Arylamine N-acetyltransferases.Semantic proximity Read ↗

Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon–DNA adduct levels in human prostateSemantic proximity Read ↗

Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias.Semantic proximity Read ↗

Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.Semantic proximity Read ↗

N-acetyltransferase-2 gene polymorphisms and prostate cancer susceptibility in Latin American patients.Semantic proximity Read ↗

A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes.Semantic proximity Read ↗

Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan.Semantic proximity Read ↗

Correlation of the genotypes for N-acetyltransferases 1 and 2 with double bladder and prostate cancers in a case-comparison study.Semantic proximity Read ↗

Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye.Semantic proximity Read ↗

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