Article
Expression in human prostate of drug- and carcinogen-metabolizing enzymes: association with prostate cancer risk.
British journal of cancer - 1 Nov 1998
Agúndez J A, Martínez C, Olivera M, Gallardo L, Ladero J M, Rosado C, Prados J, Rodriguez-Molina J, Resel L, Benítez J
Abstract excerpt
The role of two common polymorphisms of enzymes involved in the metabolism of drugs and carcinogens was studied in relation to prostate cancer. The gene encoding one of these enzymes (NAT2) is located in an area where frequent allelic loss occurs in prostate cancer. Mutations at the genes CYP2D6...
Topics
- Aged
- Aged, 80 and over
- Arylamine N-Acetyltransferase
- Carcinoma
- Cytochrome P-450 CYP2D6
- DNA Mutational Analysis
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- Prognosis
- Prostatic Neoplasms