Article
Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Dec 1998
Drago J, Padungchaichot P, Wong J Y, Lawrence A J, McManus J F, Sumarsono S H, Natoli A L, Lakso M, Wreford N, Westphal H, Kola I, Finkelstein D I
Abstract excerpt
Idiopathic Parkinson's disease involves the loss of midbrain dopaminergic neurons, resulting in the presynaptic breakdown of dopaminergic transmission in the striatum. Huntington's disease and some neurodegenerative diseases with Parkinsonian features have postsynaptic defects caused by striatal...
Topics
- Animals
- Apoptosis
- Basal Ganglia
- Diphtheria Toxin
- Enkephalins
- Gene Expression Regulation, Enzymologic
- Glial Fibrillary Acidic Protein
- Gliosis
- In Situ Hybridization
- In Situ Nick-End Labeling
- Integrases
- Mice
- Mice, Transgenic