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Article

The <i>C. elegans</i> L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2–mediated axon guidance

14 Jan 2008

Abstract excerpt

The L1 cell adhesion molecule (L1CAM) participates in neuronal development. Mutations in the human L1 gene can cause the neurological disorder CRASH (corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraplegia, and hydrocephalus). This study presents genetic data that shows that L1-like adhesion gene 2 (LAD-2), a Caenorhabditis elegans L1CAM, functions in axon pathfinding. In the SDQL neuron,...

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PMID: 18195110
DOI: 10.1083/jcb.200704178

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