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Article

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.

The Journal of experimental medicine - 15 Jun 1998

Kanakaraj P, Schafer P H, Cavender D E, Wu Y, Ngo K, Grealish P F, Wadsworth S A, Peterson P A, Siekierka J J, Harris C A, Fung-Leung W P

Abstract excerpt

Interleukin (IL)-1 is a proinflammatory cytokine with pleiotropic effects in inflammation. IL-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (MAP) kinases, c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase, as well as transcription factor nuclear factor kappaB (NF-kappaB). IL-1 signaling results in cellular responses...

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Identifiers

PMID: 9625767
DOI: 10.1084/jem.187.12.2073
PMCID: PMC2212370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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