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Article

Ribosomal release without peptidyl tRNA hydrolysis at translation termination in a eukaryotic system.

RNA (New York, N.Y.) - 1 Feb 1998

Cao J, Geballe A P

Abstract excerpt

A 22-codon upstream open reading frame (uORF2) in the human cytomegalovirus UL4 transcript leader inhibits downstream translation in cis. Previous studies revealed that the peptide product of uORF2 mediates this inhibitory effect by interfering with translation termination at its own stop codon. The block at termination results both in accumulation of the nascent uORF2 peptide linked to tRNA(Pro), the tRNA that...

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Identifiers

PMID: 9570317
PMCID: PMC1369606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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