Article
Frequency of WT1 and 11p15 constitutional aberrations and phenotypic correlation in childhood Wilms tumour patients.
European journal of cancer (Oxford, England : 1990) - 1 Nov 2012
Segers H, Kersseboom R, Alders M, Pieters R, Wagner A, van den Heuvel-Eibrink M M
Abstract excerpt
INTRODUCTION: In 9-17% of Wilms tumour patients a predisposing syndrome is present, in particular WT1-associated syndromes and overgrowth syndromes. Constitutional WT1 mutations or epigenetic changes on chromosome 11p15 have also been described in Wilms tumour patients without phenotypic abnormalities. Thus, the absence of phenotypic abnormalities does not exclude the presence of a genetic predisposition,...
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