Article
Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas.
The American journal of pathology - 1 Jan 2000
Detmar M, Velasco P, Richard L, Claffey K P, Streit M, Riccardi L, Skobe M, Brown L F
Abstract excerpt
Inhibition of the vascular endothelial growth factor (VEGF) receptor Flk-1 has been shown to prevent invasion of experimental squamous cell carcinomas (SCC). To directly investigate the role of VEGF in tumor invasion, we stably transfected human SCC-13 cells, which are characterized by a noninvasive phenotype in vivo, with expression vectors containing murine VEGF(164) in sense (SCC/VEGF+) or antisense...
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