RNA helicase A is essential for normal gastrulation.

doi:10.1073/pnas.95.23.13709

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Article

RNA helicase A is essential for normal gastrulation.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998

Lee C G, da Costa Soares V, Newberger C, Manova K, Lacy E, Hurwitz J

Abstract excerpt

RNA helicase A (RHA) is the human homologue of the Drosophila maleless protein, an essential factor for the development of male flies. Recently, it was shown that RHA cooperates with the cAMP-responsive element in mediating the cAMP-dependent transcriptional activation of a number of genes. Due t...

Topics

Animals
Embryonic and Fetal Development
Gastrula
Gene Expression Regulation, Developmental
Humans
Male
Mice
Mice, Knockout
Mutation
RNA Helicases
Recombination, Genetic

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