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Article

Ovarian tumors in Rbp9 mutants of Drosophila induce an immune response.

Molecules and cells - 31 Oct 2006

Kim Jihyun, Kim-Ha Jeongsil

Abstract excerpt

The Drosophila protein, Rbp9, is homologous to human Hu, which is reported to be involved in small cell lung cancer. Rbp9 functions in cystocyte differentiation, and mutations in Rbp9 cause ovarian tumors. Here we show that the antimicrobial peptide, Attacin, is upregulated in Rbp9 mutants, especially in ovaries where tumors form. Upregulation seems to result from activation of the NF-kappaB pathway since we...

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PMID: 17085976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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