Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual function of Ras in Raf activation.

Development (Cambridge, England) - 1 Dec 1998

Li W, Melnick M, Perrimon N

Abstract excerpt

The small guanine nucleotide binding protein p21(Ras) plays an important role in the activation of the Raf kinase. However, the precise mechanism by which Raf is activated remains unclear. It has been proposed that the sole function of p21(Ras )in Raf activation is to recruit Raf to the plasma membrane. We have used Drosophila embryos to examine the mechanism of Raf (Draf) activation in the complete absence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Drosophila
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Models, Biological

Share to Mutation

Share to Protein Binding

Share to RNA, Messenger

Source

Identifiers

PMID: 9811584
DOI: 10.1242/dev.125.24.4999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual function of Ras in Raf activation.PMID 9811584Read ↗

The Rap1 GTPase functions as a regulator of morphogenesis in vivo.Semantic proximity Read ↗

Ras and Rap: are former enemies now friends?Semantic proximity Read ↗

Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing.Semantic proximity Read ↗

Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity.Semantic proximity Read ↗

Signal transduction downstream from Ras in Drosophila.Semantic proximity Read ↗

The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination.Semantic proximity Read ↗

A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways.Semantic proximity Read ↗

Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C.Semantic proximity Read ↗

Rab11 regulates JNK and Raf/MAPK-ERK signalling pathways during Drosophila wing development.Semantic proximity Read ↗

Mutations Modulating Raf signaling in Drosophila eye development.Semantic proximity Read ↗

Multiple functions of raf proto-oncogene during development from analysis of a temperature-sensitive mutation of Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.