Article
Dual function of Ras in Raf activation.
Development (Cambridge, England) - 1 Dec 1998
Li W, Melnick M, Perrimon N
Abstract excerpt
The small guanine nucleotide binding protein p21(Ras) plays an important role in the activation of the Raf kinase. However, the precise mechanism by which Raf is activated remains unclear. It has been proposed that the sole function of p21(Ras )in Raf activation is to recruit Raf to the plasma me...
Topics
- Animals
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Enzyme Activation
- Gene Expression Regulation
- In Situ Hybridization
- Microinjections
- Models, Biological
- Mutation
- Protein Binding
- Proto-Oncogene Proteins c-raf
- Proto-Oncogene Proteins p21(ras)
- RNA, Messenger
- Repressor Proteins