Article
Overexpression of mutant ras in human melanoma increases invasiveness, proliferation and anchorage-independent growth in vitro and induces tumour formation and cachexia in vivo.
Melanoma research - 1 Jun 1999
Fujita M, Norris D A, Yagi H, Walsh P, Morelli J G, Weston W L, Terada N, Bennion S D, Robinson W, Lemon M, Maxwell I H, Yohn J J
Abstract excerpt
Malignant melanoma is the deadliest form of skin cancer. Previous studies have shown that the incidence of ras mutation increases with progression of melanoma, but that such mutations may not be present in the earliest radial growth phase melanomas. Recently it has been proposed that introduction of ras mutations into cells deficient in tumour suppressor genes such as p16 (INK4a) is sufficient to induce...
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