Article
Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau.
The American journal of pathology - 1 Nov 1998
Spillantini M G, Crowther R A, Kamphorst W, Heutink P, van Swieten J C
Abstract excerpt
Different mutations in the microtubule-associated tau protein gene have recently been identified in several families with hereditary frontotemporal dementia and Parkinsonism (FTDP-17) linked to chromosome 17q21-22. Some families show neuronal and glial deposits containing hyperphosphorylated tau...
Topics
- Aged
- Aged, 80 and over
- Chromosomes, Human, Pair 17
- Dementia
- Detergents
- Exons
- Frontal Lobe
- Hippocampus
- Humans
- Immunohistochemistry
- Microscopy, Electron
- Middle Aged
- Molecular Weight
- Mutation
- Neurofibrillary Tangles
- Neuropil Threads
- Parkinson Disease
- Pedigree