Article
Drug target validation and identification of secondary drug target effects using DNA microarrays.
Nature medicine - 1 Nov 1998
Marton M J, DeRisi J L, Bennett H A, Iyer V R, Meyer M R, Roberts C J, Stoughton R, Burchard J, Slade D, Dai H, Bassett D E, Hartwell L H, Brown P O, Friend S H
Abstract excerpt
We describe here a method for drug target validation and identification of secondary drug target effects based on genome-wide gene expression patterns. The method is demonstrated by several experiments, including treatment of yeast mutant strains defective in calcineurin, immunophilins or other g...
Topics
- Calcineurin
- Cyclosporine
- Drug Design
- Gene Expression Regulation, Fungal
- Genotype
- Immunophilins
- Immunosuppressive Agents
- Models, Biological
- Mutation
- Polymerase Chain Reaction
- Reproducibility of Results
- Saccharomyces cerevisiae
- Signal Transduction