Article
Phenotype-first screening for the identification of novel drug targets.
Drug discovery today - 15 Feb 2005
Austen Matthias, Dohrmann Cord
Abstract excerpt
Modern drug discovery is predominantly a target-driven process, where success is intricately linked to the selection of an appropriate molecular target. Ideally, there is conclusive functional evidence that a selected target is disease-relevant and, furthermore, suitable for drug development. Phenotype-first screening is a highly attractive approach for target identification because it offers the unique...
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