Towards Sustained Silencing of HER2/neu in Cancer By Epigenetic Editing

Abstract excerpt

UNLABELLED: The human epidermal growth factor receptor-2 (HER2/neu/ERBB2) is overexpressed in several cancer types. Although therapies targeting the HER2/neu protein result in inhibition of cell proliferation, the anticancer effect might be further optimized by limiting HER2/neu expression at the DNA level. Towards this aim, epigenetic editing was performed to suppress HER2/neu expression by inducing epigenetic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related gene regulation
• Share to Epigenetics and DNA Methylation
• Share to HER2/EGFR in Cancer Research