Article
Bronchioloalveolar adenocarcinoma of lung: monoclonal origin for multifocal disease.
The American journal of surgical pathology - 1 Nov 1998
Holst V A, Finkelstein S, Yousem S A
Abstract excerpt
In an attempt to understand the histogenesis and molecular pathogenesis of multifocal bronchioloalveolar lung carcinoma (BAC) we studied 28 cases of BAC using a topographic genotyping approach for the presence of K-ras exon 1 mutations and p53 loss of heterozygosity (LOH). This analytical approac...
Topics
- Adenocarcinoma, Bronchiolo-Alveolar
- Adult
- Aged
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA, Satellite
- Exons
- Female
- Genes, p53
- Genes, ras
- Genotype
- Humans
- Loss of Heterozygosity
- Lung Neoplasms
- Male
- Middle Aged
- Point Mutation