Article
Clonality status of multifocal lung adenocarcinomas based on the mutation patterns of EGFR and K-ras.
Lung cancer (Amsterdam, Netherlands) - 1 Mar 2012
Takamochi Kazuya, Oh Shiaki, Matsuoka Joe, Suzuki Kenji
Abstract excerpt
PURPOSE: The purpose of this study is to clarify the clonality status of multifocal lung adenocarcinomas based on the mutation patterns of epidermal growth factor receptor (EGFR) and K-ras. METHODS: We analyzed 82 multifocal lung adenocarcinomas from 36 patients who underwent surgical resection. Genomic DNA was extracted from formalin-fixed, paraffin-embedded tissue and analyzed for EGFR and K-ras mutations. We...
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