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Article

Essential domain of receptor tyrosine phosphatase beta (RPTPbeta) for interaction with Helicobacter pylori vacuolating cytotoxin.

The Journal of biological chemistry - 3 Dec 2004

Yahiro Kinnosuke, Wada Akihiro, Yamasaki Eiki, Nakayama Masaaki, Nishi Yoshito, Hisatsune Jyunzou, Morinaga Naoko, Sap Jan, Noda Masatoshi, Moss Joel, Hirayama Toshiya

Abstract excerpt

Helicobacter pylori produces a potent exotoxin, VacA, which causes progressive vacuolation as well as gastric injury. Although VacA was able to interact with two receptor-like protein tyrosine phosphatases, RPTPbeta and RPTPalpha, RPTPbeta was found to be responsible for gastric damage caused by VacA. To define the region of RPTPbeta involved in VacA binding, we made mutants of human cDNA RPTPbeta-B, a short...

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PMID: 15383529
DOI: 10.1074/jbc.M406473200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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