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Article

MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering.

Oncotarget - 14 Feb 2017

Montagne Rémi, Baranzelli Anne, Muharram Ghaffar, Catherine Leroy, Lesaffre Marie, Vinchent Audrey, Kherrouche Zoulika, Werkmeister Elisabeth, Cortot Alexis B, Tulasne David

Abstract excerpt

The receptor tyrosine kinase MET and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas deregulation of MET signaling is associated with tumorigenesis leading to various cancers, including lung carcinoma. Mutations in the MET kinase domain lead to constitutive kinase activity and are associated with tumorigenesis. In lung cancer, however, some mutations are found in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28061464
DOI: 10.18632/oncotarget.14499
PMCID: PMC5355264

Genes

MET
HGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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