Article
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
The Journal of experimental medicine - 26 Oct 2009
Jenne Craig N, Enders Anselm, Rivera Richard, Watson Susan R, Bankovich Alexander J, Pereira Joao P, Xu Ying, Roots Carla M, Beilke Joshua N, Banerjee Arnob, Reiner Steven L, Miller Sara A, Weinmann Amy S, Goodnow Chris C, Lanier Lewis L, Cyster Jason G, Chun Jerold
Abstract excerpt
During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer (NK) cells, we identified a strain, designated Duane, in which NK cells were reduced in blood and spleen but increased in lymph nodes (LNs) and bone marrow (BM). The accumulation of NK cells in LNs reflected a decreased ability to exit into lymph. This strain carries a point mutation within Tbx21 (T-bet), which generates...
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