Article
Experimental infection of chimpanzees with hepatitis C virus of genotype 5a: genetic analysis of the virus and generation of a standardized challenge pool.
The Journal of infectious diseases - 1 Oct 1998
Bukh J, Apgar C L, Engle R, Govindarajan S, Hegerich P A, Tellier R, Wong D C, Elkins R, Kew M C
Abstract excerpt
Six major genotypes (genotypes 1-6) of hepatitis C virus (HCV) have been identified. These genetic variants are being transmitted to chimpanzees, the only recognized animal model for the study of HCV. Genotype 5a (strain SA13), a variant found primarily in South Africa, has been transmitted to ch...
Topics
- Animals
- Disease Models, Animal
- Evolution, Molecular
- Genetic Variation
- Genotype
- Hepacivirus
- Hepatitis C
- Liver
- Molecular Sequence Data
- Pan troglodytes
- Phylogeny
- Reference Standards
- Sequence Analysis
- Viral Proteins
- Viremia