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Article

Experimental infection of chimpanzees with hepatitis C virus of genotype 5a: genetic analysis of the virus and generation of a standardized challenge pool.

The Journal of infectious diseases - 1 Oct 1998

Bukh J, Apgar C L, Engle R, Govindarajan S, Hegerich P A, Tellier R, Wong D C, Elkins R, Kew M C

Abstract excerpt

Six major genotypes (genotypes 1-6) of hepatitis C virus (HCV) have been identified. These genetic variants are being transmitted to chimpanzees, the only recognized animal model for the study of HCV. Genotype 5a (strain SA13), a variant found primarily in South Africa, has been transmitted to chimpanzees for the first time. Experimental infection of 2 chimpanzees was characterized by early appearance of viremia...

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PMID: 9806059
DOI: 10.1086/515683

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