Article
Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models.
The Journal of infectious diseases - 1 May 2010
Bukh Jens, Meuleman Philip, Tellier Raymond, Engle Ronald E, Feinstone Stephen M, Eder Gerald, Satterfield William C, Govindarajan Sugantha, Krawczynski Krzysztof, Miller Roger H, Leroux-Roels Geert, Purcell Robert H
Abstract excerpt
Chimpanzees represent the only animal model for studies of the natural history of hepatitis C virus (HCV). To generate virus stocks of important HCV variants, we infected chimpanzees with HCV strains of genotypes 1-6 and determined the infectivity titer of acute-phase plasma pools in additional animals. The courses of first- and second-passage infections were similar, with early appearance of viremia, HCV RNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.