Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.

doi:10.1172/JCI2901

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Article

Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.

The Journal of clinical investigation - 1 Jun 1998

Dorman S E, Holland S M

Abstract excerpt

IFN-gamma is critical in the immune response to mycobacterial infections, and deficits in IFN-gamma production and response have been associated with disseminated nontuberculous mycobacterial infections. Mutations in the IFN-gamma receptor ligand-binding chain (IFNgammaR1) have been shown to conf...

Topics

Disease Susceptibility
Female
Humans
Infant, Newborn
Interferon-gamma
Male
Mutation
Mycobacterium Infections
Pregnancy
Receptors, Interferon
Signal Transduction
Interferon gamma Receptor

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