Article
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency.
Science (New York, N.Y.) - 29 May 1998
Altare F, Durandy A, Lammas D, Emile J F, Lamhamedi S, Le Deist F, Drysdale P, Jouanguy E, Döffinger R, Bernaudin F, Jeppsson O, Gollob J A, Meinl E, Segal A W, Fischer A, Kumararatne D, Casanova J L
Abstract excerpt
In humans, interferon gamma (IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas...
Topics
- Animals
- Cytotoxicity, Immunologic
- Female
- Granuloma
- Humans
- Hypersensitivity, Delayed
- Interferon-gamma
- Interleukin-12
- Killer Cells, Natural
- Lymphocyte Activation
- Male
- Mice
- Mice, Knockout
- Mutation