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Article

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency.

Science (New York, N.Y.) - 29 May 1998

Altare F, Durandy A, Lammas D, Emile J F, Lamhamedi S, Le Deist F, Drysdale P, Jouanguy E, Döffinger R, Bernaudin F, Jeppsson O, Gollob J A, Meinl E, Segal A W, Fischer A, Kumararatne D, Casanova J L

Abstract excerpt

In humans, interferon gamma (IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma...

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Identifiers

PMID: 9603732
DOI: 10.1126/science.280.5368.1432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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