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Article

Human deficiencies in type 1 cytokine receptors reveal the essential role of type 1 cytokines in immunity to intracellular bacteria.

Microbes and infection - 1 Nov 2000

Ottenhoff T H, de Boer T, Verhagen C E, Verreck F A, van Dissel J T

Abstract excerpt

Studies on patients with idiopathic, severe infections due to poorly pathogenic mycobacteria and Salmonella have revealed that many of these patients are unable to produce or respond to interferon-gamma (IFN-gamma). This inability results from causative, deleterious genetic mutations in either one of four different genes in the type 1 cytokine cascade, encoding interleukin-12Rbeta1 (IL-12Rbeta1), IL-12p40,...

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PMID: 11113375
DOI: 10.1016/s1286-4579(00)01312-5

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Source receipt: pubmed, retrieved 7 Sept 2026.

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