Article
A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol.
Biochimica et biophysica acta - 8 Nov 1998
Smith M L, Burnett D, Bennett P, Waring R H, Brown H M, Williams A C, Ramsden D B
Abstract excerpt
Phenotypic differences in nicotinamide N-methyltransferase (NNMT, E. C. 2.1.1.1) activity may be due to a genetic polymorphism. We report the characterisation of the hepatic NNMT activity in cytosol from normal human livers, enzyme protein levels determined by Western blotting and ELISA and mRNA...
Topics
- Adolescent
- Adult
- Aged
- Blotting, Northern
- Blotting, Western
- Child
- Child, Preschool
- Cytosol
- DNA Primers
- Female
- Humans
- Kinetics
- Liver
- Male
- Methyltransferases
- Middle Aged
- Nicotinamide N-Methyltransferase
- Phenotype