Article
A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol.
Biochimica et biophysica acta - 8 Nov 1998
Smith M L, Burnett D, Bennett P, Waring R H, Brown H M, Williams A C, Ramsden D B
Abstract excerpt
Phenotypic differences in nicotinamide N-methyltransferase (NNMT, E. C. 2.1.1.1) activity may be due to a genetic polymorphism. We report the characterisation of the hepatic NNMT activity in cytosol from normal human livers, enzyme protein levels determined by Western blotting and ELISA and mRNA levels determined by SDS-PAGE/Northern blotting. Subjects with high NNMT activity had high levels of NNMT protein and...
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