Article
NAMPT and NAPRT1: novel polymorphisms and distribution of variants between normal tissues and tumor samples.
Scientific reports - 9 Sept 2014
Duarte-Pereira Sara, Silva Sarah S, Azevedo Luísa, Castro Luísa, Amorim António, Silva Raquel M
Abstract excerpt
Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase domain containing 1 (NAPRT1) are the main human NAD salvage enzymes. NAD regulates energy metabolism and cell signaling, and the enzymes that control NAD availability are linked to pathologies such as cancer and neurodegeneration. Here, we have screened normal and tumor samples from different tissues and populations of origin...
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